Microglia are the primary innate immune cells in the CNS. In the healthy brain, they exhibit a
unique molecular homeostatic 'signature', consisting of a specific transcriptional profile and …

A growing need exists for reliable in-vivo measurement of neuroinflammation to better
characterise the inflammatory processes underlying various diseases and to inform the …

Recent findings in human samples and animal models support the involvement of
inflammation in the development of Parkinson's disease. Nevertheless, it is currently …

Parkinson's disease is a progressive and debilitating disorder that has so far eluded
attempts to develop disease‐modifying treatment. Both epidemiological and genetic studies …

Microglial activation plays central roles in neuroinflammatory and neurodegenerative
diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein …

The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …

Microglia can transform into proinflammatory/classically activated (M1) or anti-inflammatory/
alternatively activated (M2) phenotypes following environmental signals related to …

Parkinson's disease (PD) and atypical Parkinsonian syndromes are progressive
heterogeneous neurodegenerative diseases that share clinical characteristic of …

Immune changes occur in all neurodegenerative conditions, but there are significant
differences between diseases. For Parkinson's disease (PD), the immune system …

Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people
worldwide. Two hallmarks of PD are the accumulation of alpha‐synuclein and the loss of …