Kratom—pharmacology, clinical implications, and outlook: a comprehensive review

SC Eastlack, EM Cornett, AD Kaye - Pain and therapy, 2020 - Springer
Kratom, or Mitragyna, is a tropical plant indigenous to Southeast Asia, with unique
pharmacological properties. It is commonly consumed by preparing the leaves into …

Current perspectives on the impact of Kratom use

C Veltri, O Grundmann - Substance abuse and rehabilitation, 2019 - Taylor & Francis
The leaves from the tree Mitragyna speciosa, commonly known as Kratom, in the coffee
plant family (Rubiaceae) are commonly used in their native habitat of Southeast Asia as a …

Characteristics of deaths associated with kratom use

JM Corkery, P Streete, H Claridge… - Journal of …, 2019 - journals.sagepub.com
Background: Kratom (Mitragyna speciosa Korth) use has increased in Western countries,
with a rising number of associated deaths. There is growing debate about the involvement of …

[HTML][HTML] Notes from the field: unintentional drug overdose deaths with kratom detected—27 states, July 2016–December 2017

EOM Olsen - MMWR. Morbidity and mortality weekly report, 2019 - cdc.gov
Kratom (Mitragyna speciosa), a plant native to Southeast Asia, contains the alkaloid
mitragynine, which can produce stimulant effects in low doses and some opioid-like effects …

Oxidative metabolism as a modulator of kratom's biological actions

S Chakraborty, R Uprety, ST Slocum, T Irie… - Journal of medicinal …, 2021 - ACS Publications
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly
used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of …

[HTML][HTML] Kratom policy: the challenge of balancing therapeutic potential with public safety

WC Prozialeck, BA Avery, EW Boyer… - International Journal of …, 2019 - Elsevier
Kratom (Mitragyna speciosa) is a tree-like plant indigenous to Southeast Asia. Its leaves,
and the teas brewed from them have long been used by people in that region to stave off …

[HTML][HTML] Focus: Plant-based medicine and pharmacology: Kratom and pain tolerance: A randomized, placebo-controlled, double-blind study

B Vicknasingam, WT Chooi, AA Rahim… - The Yale journal of …, 2020 - ncbi.nlm.nih.gov
Background: Kratom has a long history of traditional medicine use in Southeast Asia.
Consumption of kratom products has also been reported in the US and other regions of the …

An update on the clinical pharmacology of kratom: uses, abuse potential, and future considerations

CR McCurdy, A Sharma, KE Smith… - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Introduction Kratom (Mitragyna speciosa) has generated substantial clinical and
scientific interest as a complex natural product. Its predominant alkaloid mitragynine and …

Mitragynine attenuates morphine withdrawal effects in rats—a comparison with methadone and buprenorphine

R Hassan, C Pike See, S Sreenivasan… - Frontiers in …, 2020 - frontiersin.org
Background Opiate addiction is a major health problem in many countries. A crucial
component of the medical treatment is the management of highly aversive opiate withdrawal …

Health Effects Associated With Kratom (Mitragyna speciosa) and Polysubstance Use: A Narrative Review

CW Striley, CC Hoeflich, AT Viegas… - Substance abuse …, 2022 - journals.sagepub.com
Background: Kratom (Mitragyna speciosa) consumption and associated health effects have
raised debates in the United States. Although most people using this herb do not experience …