Mechanical ventilation is the most used short-term life support technique worldwide and is
applied daily for a diverse spectrum of indications, from scheduled surgical procedures to …

Treatment of Benzodiazepine Dependence | New England Journal of Medicine Skip to main
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Objectives: Delirium occurs frequently in adults and is an independent predictor of mortality.
However, the epidemiology and outcomes of pediatric delirium are not well-characterized …

Background Owing to the low therapeutic index of barbiturates, benzodiazepines (BZDs)
became popular in this country and worldwide many decades ago for a wide range of …

In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive
Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and …

Sleep is an important physiologic process, and lack of sleep is associated with a host of
adverse outcomes. Basic and clinical research has documented the important role circadian …

Objective: To revise the “Clinical Practice Guidelines for the Sustained Use of Sedatives and
Analgesics in the Critically Ill Adult” published in Critical Care Medicine in 2002. Methods …

Delirium is a debilitating form of brain dysfunction frequently encountered in the intensive
care unit (ICU). It is associated with increased morbidity and mortality, longer lengths of stay …

Objective: Delirium is common during critical illness and associated with adverse outcomes.
We compared characteristics and outcomes of delirious and nondelirious patients enrolled …

Sleep deprivation is common among intensive care patients and may be associated with
delirium. We investigated whether the implementation of a bundle of non‐pharmacological …