Difluoromethyl groups possess specific steric and electronic properties due to their slightly
acidic C–H bonds and the natural characteristics of fluorine atoms, which allow them to act …

We disclose the results of an investigation designed to generate insight regarding the
differences in the electronic and steric attributes of C–F, C–Cl, and C–Br bonds. Mechanistic …

α, α-Difluoromethyl carbinols are important structural motifs in many therapeutic agents and
functional materials. Herein, we developed a sustainable and efficient method for the …

Diazenes are valuable compounds that have found broad applicability because of their
optical and biological properties. We report the synthesis of alkylaryldiazenes via formal …

The asymmetric 1, 2-addition of formyl anion equivalents to carbonyl compounds is a
powerful synthetic tool that ideally provide access to highly functionalizable α-hydroxy …

The catalytic asymmetric synthesis of α, α-difluoromethylated tertiary alcohols is described,
using an asymmetric dihydroxylation reaction. This protocol using either the AD-mix-α or AD …

We report here for the first time a novel difluoromethylated ketimine building block
condensed by thioisatin and difluoroethylamine, offering efficient access to a broad range of …

The organocatalytic asymmetric addition of hydrazones to indole derivatives in the presence
of chiral Brønsted acids is reported. A large variety of substrates are tolerated and the …

α-Keto hydrazones behave as suitable precursors of nucleophilic β-amino aza-dienamine
intermediates. Using a multifunctional tert-Leucine derived amino-thiourea as the catalyst …

Room temperature ionic liquids (RTILs) have been widely used as (co) solvents in several
catalytic processes modifying, in most of the cases, the catalyst activity and/or the selectivity …