Conspectus Cross-coupling methods are the most widely used synthetic methods in
medicinal chemistry. Existing reactions are dominated by methods such as amide coupling …

We disclose a benzylic C− H oxidative coupling reaction with alcohols that proceeds through
a synergistic deprotonation, halogenation and substitution sequence. The combination of …

Methods enabling the broad diversification of C (sp3)− H bonds from a common
intermediate are especially valuable in chemical synthesis. Herein, we report a site …

Site-selective functionalization of the heterobenzylic C (sp 3)–H bonds of pyridines and
related heteroaromatic compounds presents challenges associated with the basic nitrogen …

The transition metal-free Cs2CO3/Oxone®-mediated C3-alkylation of indoles proceeds in
moderate to high yields with a variety of C4–C7 functionalized indoles and is applicable to 2 …

The skeletal editing of heteroarenes introduces new disconnections to the chemistry lexicon,
enabling the interconversion of ring systems via selective breaking/re-making of the carbon …

The field of C–H functionalization chemistry has experienced rapid growth in the past twenty
years, with increasingly powerful applications in organic synthesis. Recognizing the …

Benzylic C–H bonds can be converted into numerous functional groups, often by
mechanisms that involve hydrogen atom transfer as the key bond breaking step. The …

This work presents a novel dirhodium-catalyzed method for the conversion of aromatic
hydrocarbons to 1, 4-diamines using N-fluorobenzenesulfonimide (NFSI) as the nitrogen …

Alkylidene dihydropyridines (ADHPs) are electron-rich nucleophilic intermediates that can
be readily prepared by dearomatization of 4-alkylpyridines using chloroformate reagents …