Tumor metastasis is not only a sign of disease severity but also a major factor causing
treatment failure and cancer-related death. Therefore, studies on the molecular mechanisms …

Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein,
which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a …

Abstract Slug (SNAI2), a member of the well-conserved Snail family of transcription factors,
has multiple developmental roles, including in epithelial-to-mesenchymal transition (EMT) …

Background Transmembrane serine protease 4 (TMPRSS4) is a cell surface–anchored
serine protease. Elevated expression of TMPRSS4 correlates with poor prognosis in …

Integrins play an important role in cell adhesion by linking the cytoskeleton of cells to
components in the extracellular matrix. In this capacity, integrins cooperate with different cell …

Rationale: The role of SLUG in epithelial-mesenchymal transition during tumor progression
has been thoroughly studied, but its precise regulation remains poorly explored. Methods …

SLUG, a member of the SNAIL family of transcriptional repressors, is known to play a diverse
number of roles in the cell, and its deregulation has been observed in a variety of cancers …

Glioblastoma is the most common type of astrocytoma in the brain. Due to its high
invasiveness and chemoresistance, patients with advanced stage of glioblastoma have a …

Long non-coding RNAs (lncRNAs) have been identified to be critical mediators in various
tumors associated with cancer progression. Long non-coding RNA activated by TGF-β …

Cancer is one of the leading causes of cancer‑associated mortality worldwide. Several
strategies of treatment, including radiotherapy, have been developed and used to treat this …