Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

Photoredox chemistry with organic or transition metal agents has been reviewed in earlier
years, but such is the pace of progress that we will overlap very little with earlier …

Since the definition of the “12 Principles of Green Chemistry” more than 20 years ago,
chemists have become increasingly mindful of the need to conserve natural resources and …

C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …

Hypervalent iodine (III) compounds have found wide application in modern organic
chemistry as environmentally friendly reagents and catalysts. Hypervalent iodine reagents …

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

The conversion of unactivated carbon-hydrogen (C–H) bonds to carbon–nitrogen (C–N)
bonds is a highly valued transformation. Existing strategies typically accomplish such …

Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Rhodium (Rh) acylnitrene complexes are widely implicated in catalytic C–H amidation
reactions but have eluded isolation and structural characterization. To overcome this …