One of the primary functions of the intestinal epithelium is to transport fluid and electrolytes
to and from the luminal contents. Under normal circumstances, absorptive and secretory …

Chloride transport across cell membranes is broadly involved in epithelial fluid transport, cell
volume and pH regulation, muscle contraction, membrane excitability, and organellar …

Human intestinal enteroids derived from adult stem cells offer a relevant ex vivo system to
study biological processes of the human gut. They recreate cellular and functional features …

There is increasing evidence that the study of normal human enteroids duplicates many
known aspects of human intestinal physiology. However, this epithelial cell-only model lacks …

Diarrhea is a major cause of global mortality, and outbreaks of secretory diarrhea such as
cholera remain an important problem in the developing world. Current treatment of secretory …

Aquaporin-3 (AQP3) is a predominant water channel protein expressed in the intestine, and
plays important roles in the gut physiology and pathophysiology due to its permeability to …

Depression is a global mental disorder disease and greatly threatened human health.
Xiaochaihutang (XCHT) has been used successfully in treatment of depression for many …

Background & Aims Acute diarrheal diseases are the second most common cause of infant
mortality in developing countries. This is contributed to by lack of effective drug therapy that …

Atractylenolide III, a sesquiterpene extracted from the rhizome of Atractylodes macrocephala
(Asteraceae), exhibits pharmacological effects, including improvement of gastrointestinal …

Bile acid diarrhea is a chronic condition caused by increased delivery of bile acids to the
colon. The underlying mechanisms remain to be elucidated. To investigate genes involved …