Recent advances in ocular gene and cellular therapy rely on precisely controlled subretinal
delivery. Due to its inherent limitations, manual delivery can lead to iatrogenic damage to the …

Gene therapy using recombinant adeno‐associated virus (rAAV) vectors to treat blinding
retinal dystrophies has become clinical reality. Therapeutically impactful targeting of …

Objective To review recent technological advancement in imaging, surgical visualization,
robotics technology, and the use of artificial intelligence in surgical vitreoretinal (VR) …

The technique draws on personal experience with gene augmentation therapy by subretinal
injection in patients with choroideremia, RPE65 mutation-associated retinal dystrophy, and …

在眼科显微手术中, 传统的术中成像方式由于缺少深度信息, 限制了内部结构和手术器械的
可视化. 光学相干层析成像技术(OCT) 是一种非接触式断层成像技术, 由于其能提供深度信息 …

High-speed and wide-field optical coherence tomography (OCT) imaging is increasingly
essential for clinical applications yet faces challenges due to its inherent sensitivity roll-off …

Background: Optical coherence tomography (OCT) has recently been introduced in the
operating theatre. The aim of this review is to present the actual role of microscope …

Biallelic mutations in the RPE65 gene affect nearly 8% of Leber Congenital Amaurosis and
2% of Retinitis Pigmentosa cases. Voretigene neparvovec (VN) is the first gene therapy …

Purpose To review barriers to effective transduction of cells in the subretinal plane during
gene therapy surgery for inherited retinal dystrophies (IRD). Design Perspective. Methods …

Intraoperative optical coherence tomography (OCT) systems provide high-resolution, real-
time visualization and/or guidance of microsurgical procedures. While the use of …