Overcoming the intestinal barrier: a look into targeting approaches for improved oral drug delivery systems
Oral drug administration is one of the most preferred and simplest routes among both
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …
Nanomedicine formulations for the delivery of antiviral drugs: a promising solution for the treatment of viral infections
D Lembo, M Donalisio, A Civra… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Viral infections represent a public health problem and one of the leading
causes of global mortality. Nanomedicine strategies can be considered a powerful tool to …
causes of global mortality. Nanomedicine strategies can be considered a powerful tool to …
Nanotechnology for virus treatment
The continued emergence of novel viruses poses a significant threat to global health.
Uncontrolled outbreaks can result in pandemics that have the potential to overburden our …
Uncontrolled outbreaks can result in pandemics that have the potential to overburden our …
Challenges in oral drug delivery of antiretrovirals and the innovative strategies to overcome them
A Sosnik, R Augustine - Advanced drug delivery reviews, 2016 - Elsevier
Abstract Development of novel drug delivery systems (DDS) represents a promising
opportunity to overcome the various bottlenecks associated with the chronic antiretroviral …
opportunity to overcome the various bottlenecks associated with the chronic antiretroviral …
[HTML][HTML] Characterization of nanodiamond-based anti-HIV drug delivery to the brain
Abstract Human Immunodeficiency Virus Type 1 (HIV-1) remains one of the leading causes
of death worldwide. Present combination antiretroviral therapy has substantially improved …
of death worldwide. Present combination antiretroviral therapy has substantially improved …
[HTML][HTML] Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles
Long-acting parenteral (LAP) antiretroviral drugs have generated considerable interest for
treatment and prevention of HIV-1 infection. One new LAP is cabotegravir (CAB), a highly …
treatment and prevention of HIV-1 infection. One new LAP is cabotegravir (CAB), a highly …
Enteric-coated strategies in colorectal cancer nanoparticle drug delivery system
Colorectal cancer is one of the most common cancer diseases with the increase of cases
prevalence> 5% every year. Multidrug resistance mechanisms and non-localized therapy …
prevalence> 5% every year. Multidrug resistance mechanisms and non-localized therapy …
Effect of drug-to-lipid ratio on nanodisc-based tenofovir drug delivery to the brain for HIV-1 infection
CR Garcia, AT Rad, F Saeedinejad, A Manojkumar… - …, 2022 - Taylor & Francis
Background: Combination antiretroviral therapy has significantly advanced HIV-1 infection
treatment. However, HIV-1 remains persistent in the brain; the inaccessibility of the blood …
treatment. However, HIV-1 remains persistent in the brain; the inaccessibility of the blood …
PLA stereocomplex-chitosan nanoparticles loaded with tenofovir alafenamide as a long-acting antiretrovirals
VHB Narayanan, B Kost, A Lewandowski… - Advanced Powder …, 2023 - Elsevier
Antiretroviral therapy (ART) is a major method of HIV and AIDS treatment; however, it has
several limitations, such as poor drug availability, cytotoxicity or renal clearance of the drug …
several limitations, such as poor drug availability, cytotoxicity or renal clearance of the drug …
Enhancement of bioavailability of non-nucleoside reverse transciptase inhibitor using nanosponges
MRP Rao, C Shirsath - AAPS PharmSciTech, 2017 - Springer
Efavirenz is a non-nucleoside reverse transcriptase inhibitor which is chronically prescribed
for HIV patients. However, it exhibits solubility-limited bioavailability. Aim of this work was to …
for HIV patients. However, it exhibits solubility-limited bioavailability. Aim of this work was to …