The central role of dysregulated kinase activity in the etiology of progressive disorders,
including cancer, has fostered incremental efforts on drug discovery programs over the past …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This
review will focus on these mechanisms, ie regulation of cyclin‐dependent kinases (CDK) by …

PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4)(IC50, 0.011
μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional …

Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven
beneficial in the treatment of breast cancer. Extending this level of control to additional cell …

A pharmacological approach to inhibition of cyclin-dependent kinases 4 and 6 (Cdk4/6)
using highly selective small molecule inhibitors has the potential to provide novel cancer …

The application of fragment-based screening techniques to cyclin dependent kinase 2
(CDK2) identified multiple (> 30) efficient, synthetically tractable small molecule hits for …

Cyclin-dependent kinases (CDKs) regulate the cell division cycle, apoptosis, transcription
and differentiation in addition to functions in the nervous system. Deregulation of CDKs in …

The sustained cell proliferation resulting from dysregulation of the cell cycle and activation of
cyclin-dependent kinases (CDKs) is a hallmark of cancer. The inhibition of CDKs is a highly …

Members of the human protein kinase superfamily are the major regulatory enzymes
involved in the activity control of eukaryotic signal transduction pathways. As protein kinases …