The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of
pathogenesis in atherosclerosis, requires two steps: Priming signals promote transcription of …

Atherosclerosis is the process that underlies heart attack and stroke. A characteristic feature
of the atherosclerotic plaque is the accumulation of apoptotic cells in the necrotic core …

Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Rationale: Monocyte infiltration into the subintimal space and its intracellular lipid
accumulation are the most prominent features of atherosclerosis. To understand the …

Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and
immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive …