Analytical processes involving sample preparation, separation, and quantifying analytes in
complex mixtures are indispensable in modern-day analysis. Each step is crucial to …

The consequences of matrix effects in mass spectrometry analysis are a major issue of
concern to analytical chemists. The identification of any ion suppressing (or enhancing) …

Matrix‐dependent signal suppression or enhancement represents a major drawback in
quantitative analysis with liquid chromatography coupled to atmospheric pressure ionization …

The review discusses the pitfalls of the matrix effect in mass spectrometry detection
hyphenated to liquid chromatography separation. Matrix effect heavily influences both …

Matrix effects can significantly impede the accuracy, sensitivity, and reliability of separation
techniques presenting a formidable challenge to the analytical process. It is crucial to …

This two-volume handbook supplies food chemists with essential information on the physical
and chemical properties of nutrients, descriptions of analytical techniques, and an …

During their first period of development, the liquid chromatography–mass spectrometry
techniques were met with great enthusiasm from most end-users. An extended application …

Since the wide adoption of liquid chromatography/tandem mass spectrometry (LC/MS/MS),
the ion suppression/enhancement phenomenon is the latest barrier to high‐throughput …

Ceramides (CERs) in the upper layer of the skin, the stratum corneum (SC), play a key role
in the skin barrier function. In human SC, the literature currently reports 11 CER subclasses …

In this tutorial, the mechanism and origin of ion suppression will be investigated, as well as
ways to validate the presence, and circumvent or compensate for, the effects in LC-MS.Ion …