Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Background Castration-resistant prostate cancer (CRPC) occurs when prostate cancer
(CaP) progresses under therapy-induced castrate conditions. Several mechanisms have …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

The use of prostate-specific membrane antigen (PSMA)-directed applications in modern
prostate cancer management has evolved rapidly over the past few years, helping to …

Nuclear localization of the androgen receptor (AR) is necessary for its activation as a
transcription factor. Defining the mechanisms regulating AR nuclear localization in androgen …

Therapy resistance hinders the efficacy of anti-androgen therapies and taxane-based
chemotherapy for advanced prostate cancer (PCa). Glucocorticoid receptor (GR) signaling …

While a protein primary structure is determined by genetic code, its specific functional form is
mostly achieved in a dynamic interplay that includes actions of many enzymes involved in …

Since its discovery over 35 years ago, MDM2 has emerged as an attractive target for the
development of cancer therapy. MDM2's activities extend from carcinogenesis to immunity to …

Abstract Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic
potential. Since its identification, various cancer-promoting roles of MDM2 such as growth …