Inhibitors of monoamine oxidase (MAO) were initially used in medicine following the
discovery of their antidepressant action. Subsequently their ability to potentiate the effects of …

Nicotine is a psychoactive ingredient in tobacco that significantly contributes to the harmful
tobacco smoking habit. Nicotine dependence is more prevalent than dependence on any …

Modern imaging techniques enable researchers to observe drug actions and consequences
as they occur and persist in the brains of abusing and addicted individuals. This article …

Tobacco use through cigarette smoking is the leading preventable cause of death in the
developed world. Nicotine, a psychoactive component of tobacco, appears to play a major …

In recent years, the role of epigenetic phenomenon, such as methylation, in mediating
vulnerability to behavioral illness has become increasingly appreciated. One prominent …

Several minor tobacco alkaloids have been found to exhibit properties pharmacologically
relevant to the addictive profile of tobacco; however, little is known of their effects on a …

A major obstacle to the development of medications for nicotine dependence is the lack of
animal and human laboratory models with sufficient predictive clinical validity to support the …

Neuronal nicotinic acetylcholine receptors (nAChRs) can regulate the activity of many
neurotransmitter pathways throughout the central nervous system and are considered to be …

Regulation of nicotine levels in cigarettes and other tobacco products is now possible with
the passage of the Family Smoking Prevention and Tobacco Control Act (FSPTCA) in 2009 …

Background The World Health Organization Framework Convention on Tobacco Control
(WHO FCTC) bans all forms of tobacco advertising, promotion and sponsorship. The …