Cyclin E/CDK2: DNA replication, replication stress and genomic instability

R Fagundes, LK Teixeira - Frontiers in cell and developmental biology, 2021 - frontiersin.org
DNA replication must be precisely controlled in order to maintain genome stability.
Transition through cell cycle phases is regulated by a family of Cyclin-Dependent Kinases …

Cyclin-dependent kinase 2 inhibitors in cancer therapy: an update

S Tadesse, EC Caldon, W Tilley… - Journal of medicinal …, 2018 - ACS Publications
Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S-and M-phases
of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is …

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

SB Biering, SA Sarnik, E Wang, JR Zengel, SR Leist… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …

Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor

K Freeman-Cook, RL Hoffman, N Miller, J Almaden… - Cancer cell, 2021 - cell.com
Summary The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free
survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to …

Spectrum and degree of CDK drug interactions predicts clinical performance

P Chen, NV Lee, W Hu, M Xu, RA Ferre, H Lam… - Molecular cancer …, 2016 - AACR
Therapeutically targeting aberrant intracellular kinase signaling is attractive from a biological
perspective but drug development is often hindered by toxicities and inadequate efficacy …

Structural insights into the functional diversity of the CDK–cyclin family

DJ Wood, JA Endicott - Open biology, 2018 - royalsocietypublishing.org
Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …

Cyclin E in normal physiology and disease states

C Chu, Y Geng, Y Zhou, P Sicinski - Trends in cell biology, 2021 - cell.com
E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle
machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent …

The regulation of protein phosphorylation

LN Johnson - Biochemical Society Transactions, 2009 - portlandpress.com
Phosphorylation plays essential roles in nearly every aspect of cell life. Protein kinases
regulate signalling pathways and cellular processes that mediate metabolism, transcription …

Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB

MA Schumacher, KM Piro, W Xu, S Hansen, K Lewis… - Science, 2009 - science.org
Bacterial multidrug tolerance is largely responsible for the inability of antibiotics to eradicate
infections and is caused by a small population of dormant bacteria called persisters. HipA is …

The structure of P‐TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

S Baumli, G Lolli, ED Lowe, S Troiani, L Rusconi… - The EMBO …, 2008 - embopress.org
The positive transcription elongation factor b (P‐TEFb)(CDK9/cyclin T (CycT)) promotes
mRNA transcriptional elongation through phosphorylation of elongation repressors and …