Potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers for diseases

J Song, Y Ouyang, J Che, X Li, Y Zhao, K Yang… - Frontiers in …, 2017 - frontiersin.org
microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base
pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the …

microRNAs in breast cancer: regulatory roles governing the hallmarks of cancer

JN Goh, SY Loo, A Datta, KS Siveen… - Biological …, 2016 - Wiley Online Library
ABSTRACT A large number of etiological factors and the complexity of breast cancers
present challenges for prevention and treatment. Recently, the emergence of microRNAs …

MicroRNA profiling implies new markers of chemoresistance of triple-negative breast cancer

M Ouyang, Y Li, S Ye, J Ma, L Lu, W Lv, G Chang, X Li… - PloS one, 2014 - journals.plos.org
Objective Triple-negative breast cancer (TNBC) patients with truly chemosensitive disease
still represent a minority among all TNBC patients. The aim of the present study is to identify …

Combined delivery of temozolomide and anti‐miR221 PNA using mesoporous silica nanoparticles induces apoptosis in resistant glioma cells

A Bertucci, EA Prasetyanto, D Septiadi, A Manicardi… - Small, 2015 - Wiley Online Library
Mesoporous silica nanoparticles (MSNPs), 100 nm in size, incorporating a Cy5 fluorophore
within the silica framework, are synthesized and loaded with the anti‐cancer drug …

HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells

CM Klinge, KM Piell, CS Tooley, EC Rouchka - Scientific reports, 2019 - nature.com
MicroRNAs are dysregulated in breast cancer. Heterogeneous Nuclear Ribonucleoprotein
A2/B1 (HNRNPA2/B1) is a reader of the N (6)-methyladenosine (m6A) mark in primary …

Decoding the usefulness of non-coding RNAs as breast cancer markers

M Amorim, S Salta, R Henrique, C Jerónimo - Journal of Translational …, 2016 - Springer
Although important advances in the management of breast cancer (BC) have been recently
accomplished, it still constitutes the leading cause of cancer death in women worldwide. BC …

Cluster miRNAs and cancer: Diagnostic, prognostic and therapeutic opportunities

SP Kabekkodu, V Shukla, VK Varghese… - Wiley …, 2020 - Wiley Online Library
MiRNAs are class of noncoding RNA important for gene expression regulation in many
plants, animals and viruses. MiRNA clusters contain a set of two or more miRNA encoding …

Critical analysis of the potential for microRNA biomarkers in breast cancer management

CR Graveel, HM Calderone, JJ Westerhuis… - Breast cancer: targets …, 2015 - Taylor & Francis
Breast cancer is a complex and heterogeneous disease. Signaling by estrogen receptor
(ER), progesterone receptor (PR), and/or human EGF-like receptor 2 (HER2) is a main driver …

miR-221/222 are involved in response to sunitinib treatment in metastatic renal cell carcinoma

HWZ Khella, H Butz, Q Ding, F Rotondo, KR Evans… - Molecular therapy, 2015 - cell.com
Sunitinib is a multitargeting tyrosine kinase inhibitor used for metastatic renal cancer. There
are no biomarkers that can predict sunitinib response. Such markers are needed to avoid …

mi RNA profiling identifies deregulated mi RNA s associated with osteosarcoma development and time to metastasis in two large cohorts

GB Andersen, A Knudsen, H Hager… - Molecular …, 2018 - Wiley Online Library
Osteosarcoma (OS) is an aggressive bone tumor primarily affecting children and
adolescents. The etiology of OS is not fully understood. Thus, there is a great need to obtain …