ABSTRACT A common focus among molecular and cellular biologists is the identification of
proteins that interact with each other. Yeast two‐hybrid, cDNA expression library screening …

The Met receptor tyrosine kinase is the prototypic member of a small subfamily of growth
factor receptors that when activated induce mitogenic, motogenic, and morphogenic cellular …

The WW domain has previously been described as a motif of 38 semiconserved residues
found in seemingly unrelated proteins, such as dystrophin, Yes-associated protein (YAP) …

Crk family adaptors are widely expressed and mediate the timely formation of signal
transduction protein complexes upon a variety of extracellular stimuli, including various …

▪ Abstract A characteristic feature of cellular signal transduction pathways in eukaryotes is
the separation of catalysis from target recognition. Several modular domains that recognize …

Bruton's tyrosine kinase (Btk) plays a crucial role in B cell development. Overexpression of
Btk with a Src family kinase increases tyrosine phosphorylation and catalytic activity of Btk …

The crystal structure of the conserved core of HIV-1 Nef has been determined in complex
with the SH3 domain of a mutant Fyn tyrosine kinase (a single amino acid substitution, Arg …

Src homology 3 (SH3) and WW protein interaction domains bind specific proline-rich
sequences. However, instead of recognizing critical prolines on the basis of side chain …

CRK belongs to a family of adaptor proteins that consist mostly of SH2 and SH3 domains.
Far Western blotting with CRK SH3 has demonstrated that it binds to 135-to 145-, 160-, and …

Membrane trafficking is regulated in part by small GTP-binding proteins of the ADP-
ribosylation factor (Arf) family. Arf function depends on the controlled exchange and …