Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

[HTML][HTML] Patient education improves pain and function in people with knee osteoarthritis with better effects when combined with exercise therapy: a systematic review

AJ Goff, DDO Silva, M Merolli, EC Bell… - Journal of …, 2021 - Elsevier
Question Is patient education effective as a standalone intervention or combined with other
interventions for people with knee osteoarthritis? Design Systematic review of randomised …

Biomechanics of chondrocytes and chondrons in healthy conditions and osteoarthritis: a review of the mechanical characterisations at the microscale

S Pettenuzzo, A Arduino, E Belluzzi, A Pozzuoli… - Biomedicines, 2023 - mdpi.com
Biomechanical studies are expanding across a variety of fields, from biomedicine to
biomedical engineering. From the molecular to the system level, mechanical stimuli are …

The use of infrapatellar fat pad-derived mesenchymal stem cells in articular cartilage regeneration: a review

P Vahedi, R Moghaddamshahabi, TJ Webster… - International Journal of …, 2021 - mdpi.com
Cartilage is frequently damaged with a limited capacity for repair. Current treatment
strategies are insufficient as they form fibrocartilage as opposed to hyaline cartilage, and do …

Contribution of infrapatellar fat pad and synovial membrane to knee osteoarthritis pain

E Belluzzi, E Stocco, A Pozzuoli… - BioMed research …, 2019 - Wiley Online Library
Osteoarthritis (OA) is the most common form of joint disease and a major cause of pain and
disability in the adult population. Interestingly, there are patients with symptomatic OA …

Human cartilage biomechanics: experimental and theoretical approaches towards the identification of mechanical properties in healthy and osteoarthritic conditions

E Belluzzi, S Todros, A Pozzuoli, P Ruggieri… - Processes, 2023 - mdpi.com
Articular cartilage is a complex connective tissue with the fundamental functions of load
bearing, shock absorption and lubrication in joints. However, traumatic events, aging and …

The role of fibrosis in osteoarthritis progression

YA Rim, JH Ju - Life, 2020 - mdpi.com
Osteoarthritis (OA) is a chronic degenerative joint disease where the main characteristics
include cartilage degeneration and synovial membrane inflammation. These changes in the …

Infrapatellar fat pad features in osteoarthritis: a histopathological and molecular study

M Favero, H El-Hadi, E Belluzzi, M Granzotto… - …, 2017 - academic.oup.com
Objective The infrapatellar fat pad (IFP) is considered a local producer of adipocytokines,
suggesting a potential role in OA. The objective of this study was to evaluate the …

Infrapatellar fat pad gene expression and protein production in patients with and without osteoarthritis

E Belluzzi, V Macchi, CG Fontanella… - International journal of …, 2020 - mdpi.com
Osteoarthritis (OA) is one of the most common joint disorders. Evidence suggests that the
infrapatellar fat pad (IFP) is directly involved in OA pathology. However, a comparison …

[HTML][HTML] Infrapatellar fat pad and knee osteoarthritis

N Zeng, ZP Yan, XY Chen, GX Ni - Aging and disease, 2020 - ncbi.nlm.nih.gov
Osteoarthritis is the most prevalent arthritis typically characterized by degradation of
cartilage. However, its pathogenesis is not fully understood. Currently, osteoarthritis is best …