Importance In response to the coronavirus disease 2019 (COVID-19) pandemic, 2 mRNA
vaccines (Pfizer-BioNTech and Moderna) received emergency use authorization from the …

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic
symptoms (DIHS/DRESS) is one example of a severe delayed T-cell–mediated adverse …

Drug‐induced skin disease or cutaneous adverse drug reactions (CADRs) are terms that
encompass the clinical manifestations of the skin, mucosae and adnexa induced by a drug …

Penicillin allergy, the most frequently reported drug allergy, has been associated with
suboptimal antibiotic therapy, increased antimicrobial resistance, increased rates of …

Background: Key characteristics (KCs), properties of agents or exposures that confer
potential hazard, have been developed for carcinogens and other toxicant classes. KCs …

Drug-induced delayed hypersensitivity reactions (DHRs) is still a clinical and healthcare
burden in every country. Increasing reports of DHRs have caught our attention to explore the …

Despite the significant negative impact drug allergies can have on patient care, the
diagnosis is largely based on clinical history, and there are limited diagnostic tests that can …

Abstract Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a
predominantly drug-induced disease, with a mortality rate of 15–20%, that engages the …

A 65-year-old man experienced cough and shortness of breath 3 days after receiving the
first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine. Chest X-ray …

Delayed drug T-cell immune-mediated hypersensitivity reactions have a large clinical
heterogeneity varying from mild maculopapular exanthema (MPE) to severe cutaneous …