Synaptic neurexin complexes: a molecular code for the logic of neural circuits

TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

International union of basic and clinical pharmacology. xciv. adhesion g protein–coupled receptors

J Hamann, G Aust, D Araç, FB Engel, C Formstone… - Pharmacological …, 2015 - ASPET
The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Structural diversity of G protein-coupled receptors and significance for drug discovery

MC Lagerström, HB Schiöth - Nature reviews Drug discovery, 2008 - nature.com
G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

Neurotoxins affecting neuroexocytosis

G Schiavo, M Matteoli… - Physiological reviews, 2000 - journals.physiology.org
Nerve terminals are specific sites of action of a very large number of toxins produced by
many different organisms. The mechanism of action of three groups of presynaptic …

Mechanisms of adhesion G protein–coupled receptor activation

A Vizurraga, R Adhikari, J Yeung, M Yu… - Journal of Biological …, 2020 - ASBMB
Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

I Augustin, C Rosenmund, TC Südhof, N Brose - Nature, 1999 - nature.com
Neurotransmitter release at synapses between nerve cells is mediated by calcium-triggered
exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at the presynaptic release …

Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis …

K Kristiansen - Pharmacology & therapeutics, 2004 - Elsevier
The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …

A novel evolutionarily conserved domain of cell‐adhesion GPCRs mediates autoproteolysis

D Araç, AA Boucard, MF Bolliger, J Nguyen… - The EMBO …, 2012 - embopress.org
The G protein‐coupled receptor (GPCR) Proteolysis Site (GPS) of cell‐adhesion GPCRs
and polycystic kidney disease (PKD) proteins constitutes a highly conserved autoproteolysis …

Sticky signaling—adhesion class G protein–coupled receptors take the stage

T Langenhan, G Aust, J Hamann - Science signaling, 2013 - science.org
Adhesion-type heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane …

Structural basis of teneurin-latrophilin interaction in repulsive guidance of migrating neurons

D Del Toro, MA Carrasquero-Ordaz, A Chu, T Ruff… - Cell, 2020 - cell.com
Teneurins are ancient metazoan cell adhesion receptors that control brain development and
neuronal wiring in higher animals. The extracellular C terminus binds the adhesion GPCR …