Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40
years ago. Since that time, remarkable progress has been made in understanding its …

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How
talin and vinculin respond to forces and regulate one another remains unclear. By …

Directed cell migration is essential for cells to efficiently migrate in physiological and
pathological processes. While migrating in their native environment, cells interact with …

During embryonic morphogenesis, the heart undergoes a complex series of cellular
phenotypic maturations (eg, transition of myocytes from proliferative to quiescent or …

The ability of cells to extract biophysical information from their extracellular environment and
convert it to biochemical signals is known as mechanotransduction. Here we detail three …

Cell–matrix adhesion and cell–cell contacts are essential for the metabolism, protein
synthesis, survival, and cancer metastasis of cells. Major transmembrane receptors are the …

The focal adhesion protein vinculin connects the actin cytoskeleton, through talin and
integrins, with the extracellular matrix. Vinculin consists of a globular head and tail domain …

Integrin αIIbβ3 is a member of the integrin family of transmembrane proteins present on the
plasma membrane of platelets. Integrin αIIbβ3 is widely known to regulate the process of …

Vinculin can interact with F-actin both in recruitment of actin filaments to the growing focal
adhesions and also in capping of actin filaments to regulate actin dynamics. Using …