Intracranial aneurysms: pathology, genetics, and molecular mechanisms

Z Xu, YN Rui, JP Hagan, DH Kim - Neuromolecular medicine, 2019 - Springer
Intracranial aneurysms (IA) are local dilatations in cerebral arteries that predominantly affect
the circle of Willis. Occurring in approximately 2–5% of adults, these weakened areas are …

Genetics of intracranial aneurysms

YM Ruigrok, GJE Rinkel, C Wijmenga - The lancet neurology, 2005 - thelancet.com
Subarachnoid haemorrhage (SAH) is a subtype of stroke caused by the rupture of an
intracranial aneurysm. Genetic factors play an important part in the pathogenesis of SAH …

Susceptibility loci for intracranial aneurysm in European and Japanese populations

K Bilguvar, K Yasuno, M Niemelä, YM Ruigrok… - Nature …, 2008 - nature.com
Stroke is the world's third leading cause of death. One cause of stroke, intracranial
aneurysm, affects∼ 2% of the population and accounts for 500,000 hemorrhagic strokes …

Genetics of intracranial aneurysms

S Zhou, PA Dion, GA Rouleau - Stroke, 2018 - Am Heart Assoc
2 Stroke March 2018 environmental, and stochastic risk factors. 9 A large population-based
heritability study estimated the heritability of SAH to be 41%(95% CI, 23.7%–55.5%) …

Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at …

SK Low, A Takahashi, PC Cha… - Human molecular …, 2012 - academic.oup.com
Aneurysmal subarachnoid hemorrhage (aSAH) is the most serious subtype of stroke.
Genetic factors have been known to play an important role in the development of intracranial …

Current imaging assessment and treatment of intracranial aneurysms

L Hacein-Bey, JM Provenzale - American Journal of …, 2011 - Am Roentgen Ray Soc
OBJECTIVE. This article reviews current neuroimaging techniques used for screening,
diagnosis, and follow-up of patients with intracranial aneurysms as well as …

Pathophysiology and genetic factors in moyamoya disease

AS Achrol, R Guzman, M Lee, GK Steinberg - Neurosurgical focus, 2009 - thejns.org
Moyamoya disease is an uncommon cerebrovascular condition characterized by
progressive stenosis of the bilateral internal carotid arteries with compensatory formation of …

Molecular basis and genetic predisposition to intracranial aneurysm

G Tromp, S Weinsheimer, A Ronkainen… - Annals of …, 2014 - Taylor & Francis
Intracranial aneurysms, also called cerebral aneurysms, are dilatations in the arteries that
supply blood to the brain. Rupture of an intracranial aneurysm leads to a subarachnoid …

Genetics of intracranial aneurysms

YM Ruigrok, GJE Rinkel - Stroke, 2008 - Am Heart Assoc
Background and Purpose—Genetic determinants probably play a role in the development of
intracranial aneurysms. We review the present knowledge on this issue. Methods—This …

Genetic risk for ischemic and hemorrhagic stroke

Y Yamada, N Metoki, H Yoshida, K Satoh… - … , and vascular biology, 2006 - Am Heart Assoc
Objective—We performed an association study to identify gene polymorphisms for
assessing the genetic risk of ischemic or hemorrhagic stroke. Methods and Results—The …