Toxicity of chloroquine and hydroxychloroquine following therapeutic use or overdose

C Doyno, DM Sobieraj, WL Baker - Clinical Toxicology, 2021 - Taylor & Francis
Introduction While chloroquine, a derivative of quinine, has been used as an antimalarial for
70 years, hydroxychloroquine is now used to treat conditions such as rheumatoid arthritis …

Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19

A Cortegiani, M Ippolito, G Ingoglia, P Iozzo… - Journal of critical …, 2020 - Elsevier
Purpose To assess efficacy and safety of chloroquine (CQ)/hydroxychloroquine (HCQ) for
treatment or prophylaxis of COVID-19 in adult humans. Materials and methods MEDLINE …

Viral myocarditis: 1917–2020: From the Influenza A to the COVID-19 pandemics

SH Rezkalla, RA Kloner - Trends in cardiovascular medicine, 2021 - Elsevier
Myocarditis is common during viral infection with cases described as early as the influenza
pandemic of 1917, and the current COVID-19 pandemic is no exception. The hallmark is …

QTc prolongation in COVID‐19 patients treated with hydroxychloroquine, chloroquine, azithromycin, or lopinavir/ritonavir: a systematic review and meta‐analysis

C Diaz‐Arocutipa, A Brañez‐Condorena… - … and Drug Safety, 2021 - Wiley Online Library
Purpose Hydroxychloroquine, chloroquine, azithromycin, and lopinavir/ritonavir are drugs
that were used for the treatment of coronavirus disease 2019 (COVID‐19) during the early …

Cardiovascular adverse events associated with hydroxychloroquine and chloroquine: A comprehensive pharmacovigilance analysis of pre‐COVID‐19 reports

A Goldman, D Bomze, R Dankner… - British Journal of …, 2021 - Wiley Online Library
Aim There is a clinical need for safety data regarding hydroxychloroquine (HCQ) and
chloroquine (CQ) during the coronavirus (COVID‐19) pandemic. We analysed real‐world …

[HTML][HTML] Early COVID-19 therapy with azithromycin plus nitazoxanide, ivermectin or hydroxychloroquine in outpatient settings significantly improved COVID-19 …

FA Cadegiani, A Goren, CG Wambier… - New microbes and new …, 2021 - Elsevier
In a prospective observational study (pre-AndroCoV Trial), the use of nitazoxanide,
ivermectin and hydroxychloroquine demonstrated unexpected improvements in COVID-19 …

Targeting endolysosomal two-pore channels to treat cardiovascular disorders in the novel COronaVIrus Disease 2019

F Moccia, S Negri, P Faris, A Perna, A De Luca… - Frontiers in …, 2021 - frontiersin.org
Emerging evidence hints in favor of a life-threatening link between severe acute respiratory
syndrome coronavirus type 2 (SARS-CoV-2) and the cardiovascular system. SARS-CoV-2 …

[HTML][HTML] Cardiovascular Health and Disease in the Context of COVID-19

S Umbrajkar, RV Stankowski, S Rezkalla… - Cardiology …, 2021 - ncbi.nlm.nih.gov
First documented in China in early December 2019, the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) spread rapidly and continues to test the strength of …

Repurposing existing drugs for COVID-19: an endocrinology perspective

FA Cadegiani - BMC endocrine disorders, 2020 - Springer
Abstract Background Coronavirus Disease 2019 (COVID-19) is a multi-systemic infection
caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that …

Electrocardiographic manifestations of COVID-19: effect on cardiac activation and repolarization

A Thakore, J Nguyen, S Pollack, S Muehlbauer… - …, 2021 - thelancet.com
Background Prolonged QT intervals are reported in patients with COVID-19. Additionally,
virus particles in heart tissue and abnormal troponin levels have been reported …