Autoimmune diseases are a range of diseases in which the immune response to self- antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic …
A Dignass, R Eliakim, F Magro, C Maaser… - Journal of Crohn's …, 2012 - academic.oup.com
Ulcerative colitis is a lifelong disease arising from an interaction between genetic and environmental factors, observed predominantly in the developed countries of the world. The …
EO Glocker, D Kotlarz, K Boztug… - … England Journal of …, 2009 - Mass Medical Soc
Background The molecular cause of inflammatory bowel disease is largely unknown. Methods We performed genetic-linkage analysis and candidate-gene sequencing on …
Abstract Discs large homolog 5 (DLG5), a key member of the membrane-associated guanylate kinase (MAGUKs) family, is a scaffold molecule for signal transduction complexes …
The gut mucosa is constantly challenged by a bombardment of foreign antigens and environmental microorganisms. As such, the precise regulation of the intestinal barrier …
Research over the last few years has revealed significant haplotype structure in the human genome. The characterization of these patterns, particularly in the context of medical genetic …
DC Baumgart, SR Carding - The Lancet, 2007 - thelancet.com
Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …
Genetic factors strongly affect susceptibility to common diseases and also influence disease- related quantitative traits. Identifying the relevant genes has been difficult, in part because …
Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory conditions that are immunologically mediated. Although their exact etiologies remain …