The water permeability of biological membranes has been a longstanding problem in
physiology, but the proteins responsible for this remained unknown until discovery of the …

The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of
how water specifically crosses biological membranes. In the kidney, at least seven …

During development, distinct progenitors contribute to the nephrons versus the ureteric
epithelium of the kidney. Indeed, previous human pluripotent stem-cell-derived models of …

Aquaporins (AQP) are integral membrane proteins that serve as channels in the transfer of
water, and in some cases, small solutes across the membrane. They are conserved in …

The aquaporin-2 (AQP2) vasopressin water channel is translocated to the apical membrane
upon vasopressin stimulation. Phosphorylation of serine 256 of AQP2 by cAMP-dependent …

The goal of this study was to compare single channel water and glycerol permeabilities of
mammalian aquaporins (AQP) 1–5 and the major intrinsic protein of lens fiber (MIP). Each of …

The kidney is the central organ involved in maintaining water and sodium balance. In human
kidneys, nine aquaporins (AQPs), including AQP1–8 and AQP11, have been found and are …

The discovery of aquaporin membrane water channels by Agre and coworkers answered a
long-standing biophysical question of how water specifically crosses biologic membranes …

A simple method for antigen retrieval in tissue sections and cell cultures is described.
Because many antibodies recognize denatured proteins on western blots, but are poorly …

The mercurial insensitive water channel (MIWC, AQP-4) is a water-selective transporter
expressed at the basolateral plasma membrane of principal cells in kidney collecting duct …