Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Abstract 'Enriched environments' are a key experimental paradigm to decipher how
interactions between genes and environment change the structure and function of the brain …

Adult hippocampal neurogenesis is the process by which new functional neurons are added
to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of …

There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …

What has become standard textbook knowledge over the last decade was a hotly debated
matter a decade earlier: the proposition that new neurons are generated in the adult …

Mammalian sleep expression and regulation have historically been thought to reflect the
activity of neurons. Changes in other brain cells (glia) across the sleep-wake cycle and their …

Background: The hippocampus is one of the sites in the mammalian brain that is capable of
continuously generating controversy. Adult neurogenesis is a remarkable process, and yet …

Alzheimer's disease (AD) is the most common form of dementia and seriously affects the
quality of life of the elderly. Neurodegeneration is closely related to hippocampal dysfunction …

Recombinant adeno-associated virus (rAAV) has been widely used as a viral vector across
mammalian biology and has been shown to be safe and effective in human gene therapy …

The generation of new neurons in the adult brain is a currently accepted phenomenon. Over
the past few decades, the subventricular zone and the hippocampal dentate gyrus have …