The characterization of mouse models of human disease is essential for understanding the
underlying pathophysiology and developing new therapeutics. Many diseases are often …

Endothelins are potent regulators of vascular tone, which also have mitogenic, apoptotic,
and immunomodulatory properties (Rubanyi and Polokoff, 1994; Kedzierski and …

Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface
antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal …

Microbial capsular antigens are effective vaccines but are chemically and immunologically
diverse, resulting in a major barrier to their use against multiple pathogens. A β-(1→ 6) …

Background Cerebral malaria (CM) is a neurological syndrome that includes coma and
seizures following malaria parasite infection. The pathophysiology is not fully understood …

Neurological impairments are frequently detected in children surviving cerebral malaria
(CM), the most severe neurological complication of infection with Plasmodium falciparum …

Cerebral malaria (CM) is the most severe manifestation of Plasmodium falciparum infection
in children and non-immune adults. Previous work has documented a persistent cognitive …

Cerebral malaria (CM) is a leading cause of death in Plasmodium falciparum infections. In
the Plasmodium berghei ANKA (PbA) murine model, CM pathogenesis is associated with …

Malaria is a fatal human parasitic disease transmitted by a mosquito vector. Although the
evolution of within-host malaria virulence has been the focus of many theoretical and …

Purpose To evaluate the effects of sepsis on brain microvasculature leukocyte rolling and
adherence, myeloperoxidase (MPO) activity, cytokine and chemokine concentrations, and …