Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

[HTML][HTML] Advancing application of mesenchymal stem cell-based bone tissue regeneration

F Shang, Y Yu, S Liu, L Ming, Y Zhang, Z Zhou, J Zhao… - Bioactive materials, 2021 - Elsevier
Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …

[HTML][HTML] Mesenchymal stromal cell therapeutic delivery: translational challenges to clinical application

H Caplan, SD Olson, A Kumar, M George… - Frontiers in …, 2019 - frontiersin.org
For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression

TR Doeppner, J Herz, A Görgens… - Stem cells …, 2015 - academic.oup.com
Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent
evidence has suggested that stem and progenitor cells alike promote postischemic …

Role of mesenchymal stem cells in bone regenerative medicine: what is the evidence?

A Oryan, A Kamali, A Moshiri… - Cells Tissues …, 2017 - karger.com
Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …

MSCs: delivery routes and engraftment, cell‐targeting strategies, and immune modulation

TJ Kean, P Lin, AI Caplan, JE Dennis - Stem cells international, 2013 - Wiley Online Library
Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and
in clinical trials for multiple disease states. The differentiation, trophic, and …

[HTML][HTML] Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats

S Dabrowska, A Andrzejewska, D Strzemecki… - Journal of …, 2019 - Springer
Background Ischemic stroke is the major cause of long-term severe disability and death in
aged population. Cell death in the infarcted region of the brain induces immune reaction …

Engineering mesenchymal stem cells for regenerative medicine and drug delivery

JS Park, S Suryaprakash, YH Lao, KW Leong - Methods, 2015 - Elsevier
Researchers have applied mesenchymal stem cells (MSC) to a variety of therapeutic
scenarios by harnessing their multipotent, regenerative, and immunosuppressive properties …

Macrophage-based cell therapies: the long and winding road

S Lee, S Kivimäe, A Dolor, FC Szoka - Journal of Controlled Release, 2016 - Elsevier
In the quest for better medicines, attention is increasingly turning to cell-based therapies.
The rationale is that infused cells can provide a targeted therapy to precisely correct a …

[HTML][HTML] Mesenchymal stem cell-mediated effects of tumor support or suppression

KJ Rhee, JI Lee, YW Eom - International journal of molecular sciences, 2015 - mdpi.com
Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many
studies have reported that tumor progression and metastasis increase by MSCs. In contrast …