Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Alzheimer's disease (AD) is a serious neurodegenerative disease. It is widely believed that
the accumulation of amyloid beta (Aβ) in neurons around neurofibrillary plaques is the main …

Accurate prediction of protein stability upon mutation enables rational engineering of new
proteins and insights into protein evolution and monogenetic diseases caused by single …

γ-Secretase cleaves the C99 fragment of the amyloid precursor protein, leading to formation
of aggregated β-amyloid peptide central to Alzheimer's disease, and Notch, essential for cell …

Accurate prediction of protein stability changes upon mutation (ΔΔG) is increasingly
important to evolution studies, protein engineering, and screening of disease‐causing gene …

The 4-subunit intramembrane protease complex γ-secretase cleaves many substrates
including fragments of the β-amyloid precursor protein (APP), leading to formation of Aβ …

The binding affinity of the SARS-CoV-2 spike (S)-protein to the human membrane protein
ACE2 is critical for virus function. Computational structure-based screening of new S-protein …

Computational approaches to study of neuronal impairment is rapidly evolving, as
experiments and intuition alone do not explain the complexity of the brain system. An …

The four‐subunit protease complex γ‐secretase cleaves many single‐pass transmembrane
(TM) substrates, including Notch and β‐amyloid precursor protein to generate amyloid‐β …

Predicting the impact of new emerging virus mutations is of major interest in surveillance
and for understanding the evolutionary forces of the pathogens. The SARS-CoV-2 surface …