Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

H Luo, CT Vong, H Chen, Y Gao, P Lyu, L Qiu, M Zhao… - Chinese medicine, 2019 - Springer
Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer
activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects …

Therapeutic potential of certain terpenoids as anticancer agents: a scoping review

S Kamran, A Sinniah, MAM Abdulghani, MA Alshawsh - Cancers, 2022 - mdpi.com
Simple Summary Terpenoids are bioactive compounds with a variety of pharmacological
activities, including anticancer activity. This review paper aimed to focus on the anticancer …

Resistance and overcoming resistance in breast cancer

A Luque-Bolivar, E Pérez-Mora… - … Cancer: Targets and …, 2020 - Taylor & Francis
The incidence and mortality of breast cancer (BC) have increased in recent years, and BC is
the main cause of cancer-related death in women worldwide. One of the most significant …

Artesunate inhibits growth of sunitinib-resistant renal cell carcinoma cells through cell cycle arrest and induction of ferroptosis

SD Markowitsch, P Schupp, J Lauckner… - Cancers, 2020 - mdpi.com
Simple Summary Renal cell carcinoma (RCC) is the most common kidney malignancy. Due
to development of therapy resistance, efficacy of conventional drugs such as sunitinib is …

Artesunate impairs growth in cisplatin-resistant bladder cancer cells by cell cycle arrest, apoptosis and autophagy induction

F Zhao, O Vakhrusheva, SD Markowitsch, KS Slade… - Cells, 2020 - mdpi.com
Cisplatin, which induces DNA damage, is standard chemotherapy for advanced bladder
cancer (BCa). However, efficacy is limited due to resistance development. Since artesunate …

Antimalarial and anticancer properties of artesunate and other artemisinins: current development

P Khanal - Monatshefte für Chemie-Chemical Monthly, 2021 - Springer
This review provides a recent perspective of artesunate and other artemisinins as
antimalarial drugs and their uses in cancer therapy. Artesunate is an artemisinin derivative …

Artemisinins as anticancer drugs: Novel therapeutic approaches, molecular mechanisms, and clinical trials

C Xu, H Zhang, L Mu, X Yang - Frontiers in Pharmacology, 2020 - frontiersin.org
Artemisinin and its derivatives have shown broad-spectrum antitumor activities in vitro and in
vivo. Furthermore, outcomes from a limited number of clinical trials provide encouraging …

Understanding breast cancer: From conventional therapies to repurposed drugs

B Costa, I Amorim, F Gärtner, N Vale - European Journal of Pharmaceutical …, 2020 - Elsevier
Breast cancer is the most common cancer among women and is considered a developed
country disease. Moreover, is a heterogenous disease, existing different types and stages of …

Recent pharmacological advances in the repurposing of artemisinin drugs

Y Meng, N Ma, H Lyu, YK Wong… - Medicinal research …, 2021 - Wiley Online Library
Artemisinins are a family of sesquiterpene lactones originally derived from the sweet
wormwood (Artemisia annua). Beyond their well‐characterized role as frontline antimalarial …

Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells

X Yao, C Zhao, H Yin, KW Wang, J Gao - Acta Pharmacologica Sinica, 2020 - nature.com
Sorafenib is currently the standard chemotherapy drug for treatment of advanced
hepatocellular carcinoma (HCC). But its efficacy requires improvement, it is imperative to …