Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …

RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …

RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …

Pattern recognition receptors (PRRs) survey intra-and extracellular spaces for pathogen-
associated molecular patterns (PAMPs) within microbial products of infection. Recognition …

Mammalian cells possess mechanisms to detect and defend themselves from invading
viruses. In the cytosol, the RIG-I-like receptors (RLRs), RIG-I (retinoic acid-inducible gene I; …

Antiviral immunity is initiated upon host recognition of viral products via non-self molecular
patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition …

Inflammation is triggered when innate immune cells detect infection or tissue injury.
Surveillance mechanisms involve pattern recognition receptors (PRRs) on the cell surface …

Microbial infections are recognized by the innate immune system through germline-encoded
pattern recognition receptors (PRRs). As most microbial pathogens contain DNA and/or …

The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen
sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect …

Abstract The Cul4–Rbx1–DDB1–Cereblon E3 ubiquitin ligase complex is the target of
thalidomide, lenalidomide and pomalidomide, therapeutically important drugs for multiple …