Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

Parkinson's disease is a debilitating, age-associated movement disorder. A central aspect of
the pathophysiology of Parkinson's disease is the progressive demise of midbrain dopamine …

Genome-wide association studies (GWAS) have identified numerous genetic variants
associated with complex diseases, but mechanistic insights are impeded by a lack of …

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …

We examined a large family with autosomal dominant PD (average age of onset, 34 years),
ranging clinically from dementia with Lewy bodies to typical PD (3). Neuropathological …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Parkinson disease (PD) is a multifactorial neurodegenerative disease that was long
considered the result of environmental factors. In the past 15 years, however, a genetic …

Genomic triplication of the α-synuclein gene (SNCA) has been reported to cause hereditary
early-onset parkinsonism with dementia. These findings prompted us to screen for …

Although most cases of Alzheimer's and Parkinson's disease are sporadic, some cases are
clearly familial. This review, part of the Genomic Medicine series, examines the genetics of …

Research in Parkinson's disease (PD) genetics has been extremely prolific over the past
decade. More than 13 loci and 9 genes have been identified, but their implication in PD is …