Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Abstract microRNAs (miRNAs) are suggested to play substantial roles in regulating the
development and various physiologic functions of the central nervous system (CNS). These …

Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …

Dysfunction of cell bioenergetics is a common feature of neurodegenerative diseases, the
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …

Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune
bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the …

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of …

The increase in human life expectancy has become a challenge to reduce the deleterious
consequences of aging. Nowadays, an increasing number of the population suffer from age …

Prolonged exposure to glucocorticoids, the main stress hormones, damages the brain and is
a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid …

Alzheimer's disease (AD), the most common form of dementia, has increasing incidence,
increasing mortality rates, and poses a huge burden on healthcare. None of the currently …