New horizons in human sperm selection for assisted reproduction

B Nixon, JE Schjenken, ND Burke… - Frontiers in …, 2023 - frontiersin.org
Male infertility is a commonly encountered pathology that is estimated to be a contributory
factor in approximately 50% of couples seeking recourse to assisted reproductive …

Global profiling of the proteomic changes associated with the post-testicular maturation of mouse spermatozoa

DA Skerrett-Byrne, AL Anderson, EG Bromfield… - Cell Reports, 2022 - cell.com
Spermatozoa acquire fertilization potential during passage through a highly specialized
region of the extratesticular ductal system known as the epididymis. In the absence of de …

Time‐resolved proteomic profiling of cigarette smoke‐induced experimental chronic obstructive pulmonary disease

DA Skerrett‐Byrne, EG Bromfield, HC Murray… - …, 2021 - Wiley Online Library
Background and objective Chronic obstructive pulmonary disease (COPD) is the third
leading cause of illness and death worldwide. Current treatments aim to control symptoms …

High-fat diet alters male seminal plasma composition to impair female immune adaptation for pregnancy in mice

JE Schjenken, LM Moldenhauer, DJ Sharkey… - …, 2021 - academic.oup.com
Paternal experiences and exposures before conception can influence fetal development
and offspring phenotype. The composition of seminal plasma contributes to paternal …

High resolution proteomic analysis of subcellular fractionated boar spermatozoa provides comprehensive insights into perinuclear theca-residing proteins

M Zhang, RZ Chiozzi, DA Skerrett-Byrne… - Frontiers in cell and …, 2022 - frontiersin.org
The perinuclear theca (PT) is a highly condensed, largely insoluble protein structure that
surrounds the nucleus of eutherian spermatozoa. Recent reports have indicated that the PT …

Synergistic targeting of DNA-PK and KIT signaling pathways in KIT mutant acute myeloid leukemia

HC Murray, K Miller, JS Brzozowski, RGS Kahl… - Molecular & Cellular …, 2023 - ASBMB
Acute myeloid leukemia (AML) is the most common and aggressive form of acute leukemia,
with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating …

Elucidation of the protein composition of mouse seminal vesicle fluid

SP Smyth, B Nixon, AL Anderson, HC Murray… - …, 2022 - Wiley Online Library
The seminal vesicles are male accessory sex glands that contribute the major portion of the
seminal plasma in which mammalian spermatozoa are bathed during ejaculation. In …

Exposure to acrylamide induces zygotic genome activation defects of mouse embryos

SL Wu, JQ Ju, YM Ji, HL Zhang, YJ Zou… - Food and Chemical …, 2023 - Elsevier
Acrylamide (ACR) is an important chemical raw material for wastewater treatment, paper
industry and textile industry, which is widely exposed from occupational, environmental and …

Proteomic analysis of spermatozoa reveals caseins play a pivotal role in preventing short-term periods of subfertility in stallions

RA Griffin, A Swegen, MA Baker, RA Ogle… - Biology of …, 2022 - academic.oup.com
Stallions experience transient fluctuations in fertility throughout the breeding season.
Considering pregnancy diagnoses cannot be ascertained until~ 14 days postbreeding, the …

Immune Regulation of Seminal Plasma on the Endometrial Microenvironment: Physiological and Pathological Conditions

Q Shen, X Wu, J Chen, C He, Z Wang, B Zhou… - International Journal of …, 2023 - mdpi.com
Seminal plasma (SP) accounts for more than 90% of semen volume. It induces inflammation,
regulates immune tolerance, and facilitates embryonic development and implantation in the …