Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …

Next-generation transcriptomics in combination with imaging-based approaches have
emerged as powerful tools for the characterization of dorsal root ganglion (DRG) neuronal …

With concurrent global epidemics of chronic pain and opioid use disorders, there is a critical
need to identify, target and manipulate specific cell populations expressing the mu-opioid …

The term 'opioids' refers to both the natural compounds ('opiates') which are extracted from
the opium poppy plant (Papaver somniferum) and their semi-synthetic and synthetic …

This paper is the forty-fifth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Voltage-gated calcium channels in sensory neurons underlie processes ranging from
neurotransmitter release to gene expression and remain a therapeutic target for the …

Bradykinin is a peptide implicated in inflammatory pain in both humans and rodents. In
rodent sensory neurons, activation of B1 and B2 bradykinin receptors induces neuronal …

Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root (DRG) and trigeminal ganglia. These neurons are …