Lipopolysaccharide endotoxins

CRH Raetz, C Whitfield - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract Bacterial lipopolysaccharides (LPS) typically consist of a hydrophobic domain
known as lipid A (or endotoxin), a nonrepeating “core” oligosaccharide, and a distal …

Biosynthesis of lipopolysaccharide O antigens

C Whitfield - Trends in microbiology, 1995 - cell.com
Lipopolysaccharide O antigens are important virulence determinants for many bacteria. O-
antigen synthesis is an interesting problem in cell-surgace assembly. There are two known …

Biosynthesis and expression of cell-surface polysaccharides in gram-negative bacteria

C Whitfield, MA Valvano - Advances in microbial physiology, 1993 - Elsevier
Publisher Summary This chapter provides an overview of the molecular mechanisms
involved in synthesis and expression of cell-surface polysaccharides in Gram-negative …

Genomic organization of LPS-specific loci

PP Reeves, L Wang - Pathogenicity Islands and the Evolution of …, 2002 - Springer
Lipopolysaccharide (LPS) genes have many of the characteristics of PAIs but also differ in
significant ways. Lipopolysaccharide differs from the products of most PAI genes in that it is …

C-terminal half of Salmonella enterica WbaP (RfbP) is the galactosyl-1-phosphate transferase domain catalyzing the first step of O-antigen synthesis

L Wang, D Liu, PR Reeves - Journal of bacteriology, 1996 - Am Soc Microbiol
We previously showed that the product of the wbaP gene of Salmonella enterica serovar
Typhimurium has two functions: it is involved in the first step of O-antigen synthesis (the …

Gene products required for surface expression of the capsular form of the group 1 K antigen in Escherichia coli (O9a:K30)

J Drummelsmith, C Whitfield - Molecular microbiology, 1999 - Wiley Online Library
The group 1 K30 antigen from Escherichia coli (O9a: K30) is present on the cell surface as
both a capsular structure composed of high‐molecular‐weight K30 polysaccharide and as …

Polyprenyl phosphates: synthesis and structure-activity relationship for a biosynthetic system of Salmonella anatum O-specific polysaccharide

LL Danilov, TN Druzhinina, NA Kalinchuk… - Chemistry and physics …, 1989 - Elsevier
A series of polyprenyl phosphates with modified structure of polyprenyl residue was
prepared through phosphorylation of polyprenyl trichloroacetimidates with phosphoric acid …

Functional analysis of the galactosyltransferases required for biosynthesis of D-galactan I, a component of the lipopolysaccharide O1 antigen of Klebsiella …

S Guan, AJ Clarke, C Whitfield - Journal of bacteriology, 2001 - Am Soc Microbiol
ABSTRACT d-Galactan I is an O-antigenic polymer with the repeat unit structure [→ 3)-β-d-
Gal f-(1→ 3)-α-d-Gal p-(1→], that is found in the lipopolysaccharide of Klebsiella …

Biosynthesis of bacterial polysaccharide chains composed of repeating units

VN Shibaev - Advances in carbohydrate chemistry and biochemistry, 1987 - Elsevier
Publisher Summary This chapter describes the biosynthesis of bacterial polysaccharide
chains composed of repeating units. A number of complicated polymers having chains …

Role of Rfe and RfbF in the initiation of biosynthesis of D-galactan I, the lipopolysaccharide O antigen from Klebsiella pneumoniae serotype O1

BR Clarke, D Bronner, WJ Keenleyside… - Journal of …, 1995 - Am Soc Microbiol
The 6.6-kb rfb gene cluster from Klebsiella pneumoniae serotype O1 (rfbKpO1) contains six
genes whose products are required for the biosynthesis of a lipopolysaccharide O antigen …