With their power to shape animal morphology, few genes have captured the imagination of
biologists as the evolutionarily conserved members of the Hox clusters have done. Recent …

Hox genes encode homeodomain-containing transcription factors that pattern the body axes
of animal embryos. It is well established that the exquisite DNA-binding specificity that …

Hox proteins are well known for executing highly specific functions in vivo, but our
understanding of the molecular mechanisms underlying gene regulation by these …

Transcription factors (TFs) control gene expression by binding to genomic DNA in a
sequence-specific manner. Mutations in TF binding sites are increasingly found to be …

Homeotic (Hox) genes regulate the identity of structures along the anterior-posterior axis of
most animals. The low DNA-binding specificities of Hox proteins have raised the question of …

Despite decades of research, morphogenesis along the various body axes remains one of
the major mysteries in developmental biology. A milestone in the field was the realisation …

Despite the recent synthesis of developmental genetics and evolutionary biology, current
theories of adaptation are still strictly phenomenological and do not yet consider the …

Development of the vulva in C. elegans is mediated by the combinatorial action of several
convergent regulatory inputs, three of which, the Ras, Wnt and Rb-related pathways, act by …

Hox proteins control the differentiation of serially iterated structures in arthropods and
chordates by differentially regulating many target genes. It is yet unclear to what extent Hox …

The Drosophila protein DEAF‐1 is a sequence‐specific DNA binding protein that was
isolated as a putative cofactor of the Hox protein Deformed (Dfd). In this study, we analyze …