Dendritic cell subsets in cancer immunity and tumor antigen sensing
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
Immunogenic cell stress and death
Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity
B Wiernicki, S Maschalidi, J Pinney, S Adjemian… - Nature …, 2022 - nature.com
Immunogenic cell death significantly contributes to the success of anti-cancer therapies, but
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …
immunogenicity of different cell death modalities widely varies. Ferroptosis, a form of cell …
Targeting immunogenic cell death in cancer
A Ahmed, SWG Tait - Molecular oncology, 2020 - Wiley Online Library
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …
Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors
Conventional chemotherapeutics have been developed into clinically useful agents based
on their ability to preferentially kill malignant cells, generally owing to their elevated …
on their ability to preferentially kill malignant cells, generally owing to their elevated …
[HTML][HTML] Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity
Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
CD8+ T cell-mediated cancer clearance is often suppressed by the interaction between
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …
DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
Type I interferon-mediated tumor immunity and its role in immunotherapy
R Yu, B Zhu, D Chen - Cellular and Molecular Life Sciences, 2022 - Springer
Immune checkpoint blockade (ICB) therapies have achieved remarkable clinical responses
in patients with many different types of cancer; however, most patients who receive ICB …
in patients with many different types of cancer; however, most patients who receive ICB …
[HTML][HTML] Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
L Galluzzi, I Vitale, S Warren, S Adjemian… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune
response associated with immunological memory, provided they display sufficient …
response associated with immunological memory, provided they display sufficient …