MicroRNAs in kidney injury and disease

N Mahtal, O Lenoir, C Tinel, D Anglicheau… - Nature Reviews …, 2022 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by
degrading or repressing the translation of their target messenger RNAs. As miRNAs are …

A glimpse of the mechanisms related to renal fibrosis in diabetic nephropathy

LF Zeng, Y Xiao, L Sun - Renal Fibrosis: Mechanisms and Therapies, 2019 - Springer
Diabetic nephropathy (DN) is a common kidney disease in people with diabetes, which is
also a serious microvascular complication of diabetes and the main cause of end-stage …

Exosomal miRNA‐215‐5p Derived from Adipose‐Derived Stem Cells Attenuates Epithelial–Mesenchymal Transition of Podocytes by Inhibiting ZEB2

J Jin, Y Wang, L Zhao, W Zou, M Tan… - BioMed research …, 2020 - Wiley Online Library
Background. Podocyte migration is actively involved in the process of podocyte loss and
proteinuria production, which is closely associated with the development of diabetic …

Astragaloside IV inhibits glucose-induced epithelial-mesenchymal transition of podocytes through autophagy enhancement via the SIRT–NF-κB p65 axis

X Wang, Y Gao, N Tian, T Wang, Y Shi, J Xu, B Wu - Scientific reports, 2019 - nature.com
Both autophagy and podocyte epithelial-mesenchymal transition (EMT) are critical factors in
glomerular diseases that involve proteinuria and fibrosis. Here, we sought to determine …

Micro RNA‐30a ameliorates hepatic fibrosis by inhibiting Beclin1‐mediated autophagy

J Chen, Y Yu, S Li, Y Liu, S Zhou… - Journal of Cellular …, 2017 - Wiley Online Library
We explored the role of micro RNA‐30a (miR‐30a) and the mechanism involved in hepatic
fibrosis. MiR‐30a overexpression was achieved by miR‐30a mimics transfection in hepatic …

MicroRNAs as master regulators of glomerular function in health and disease

P Trionfini, A Benigni - Journal of the American Society of …, 2017 - journals.lww.com
MicroRNAs (miRNAs) are important regulators of gene expression, and the dysregulation of
miRNAs is a common feature of several diseases. More miRNAs are identified almost daily …

Circular RNA circHIPK3 promotes the proliferation and differentiation of chicken myoblast cells by sponging miR-30a-3p

B Chen, J Yu, L Guo, MS Byers, Z Wang, X Chen, H Xu… - Cells, 2019 - mdpi.com
Circular RNAs and microRNAs widely exist in various species and play crucial roles in
multiple biological processes. It is essential to study their roles in myogenesis. In our …

Complex determinants of epithelial: mesenchymal phenotypic plasticity in ovarian cancer

Y Klymenko, O Kim, MS Stack - Cancers, 2017 - mdpi.com
Unlike most epithelial malignancies which metastasize hematogenously, metastasis of
epithelial ovarian cancer (EOC) occurs primarily via transcoelomic dissemination …

Diabetic nephropathy: the regulatory interplay between epigenetics and microRNAs

H Sankrityayan, YA Kulkarni, AB Gaikwad - Pharmacological research, 2019 - Elsevier
Diabetic nephropathy (DN) is still one of the leading causes of end-stage renal disease
despite the emergence of different therapies to counter the metabolic, hemodynamic and …

MicroRNAs-mediated epithelial-mesenchymal transition in fibrotic diseases

XZ Zou, T Liu, ZC Gong, CP Hu, Z Zhang - European journal of …, 2017 - Elsevier
MicroRNAs (miRNAs), a large family of small and highly conserved non-coding RNAs,
regulate gene expression through translational repression or mRNA degradation. Aberrant …