[HTML][HTML] The impact of Di-(2-ethylhexyl) Phthalate and Mono (2-ethylhexyl) Phthalate in placental development, function, and pathophysiology

LD Martínez-Razo, A Martínez-Ibarra… - Environment …, 2021 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a chemical widely distributed in the
environment as is extensively used in the plastic industry. DEHP is considered an endocrine …

Placenta disrupted: endocrine disrupting chemicals and pregnancy

J Gingrich, E Ticiani, A Veiga-Lopez - Trends in Endocrinology & …, 2020 - cell.com
Endocrine disrupting chemicals (EDCs) are chemicals that can interfere with normal
endocrine signals. Human exposure to EDCs is particularly concerning during vulnerable …

Cumulative exposure to phthalates and their alternatives and associated female reproductive health: body burdens, adverse outcomes, and underlying mechanisms

X Weng, Q Zhu, C Liao, G Jiang - Environmental Science & …, 2023 - ACS Publications
The global birth rate has recently shown a decreasing trend, and exposure to environmental
pollutants has been identified as a potential factor affecting female reproductive health …

[HTML][HTML] Association of phthalate exposure with thyroid function during pregnancy

A Derakhshan, H Shu, MAC Broeren, CH Lindh… - Environment …, 2021 - Elsevier
Background The extent of thyroid disruptive effects of phthalates during pregnancy remains
unclear. Aim To investigate the association of maternal urinary phthalates with markers of …

[HTML][HTML] Killing two birds with one stone: Pregnancy is a sensitive window for endocrine effects on both the mother and the fetus

I Plante, LM Winn, C Vaillancourt, P Grigorova… - Environmental …, 2022 - Elsevier
Pregnancy is a complex process requiring tremendous physiological changes in the mother
in order to fulfill the needs of the growing fetus, and to give birth, expel the placenta and …

A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus

RL Birru, HW Liang, F Farooq, M Bedi, M Feghali… - Environmental …, 2021 - Springer
Per-and polyfluoroalkyl substances (PFAS) have been found to be associated with
gestational diabetes mellitus (GDM) development, a maternal health disorder in pregnancy …

The Role of Peroxisome Proliferator–Activated Receptor Gamma () in Mono(2-ethylhexyl) Phthalate (MEHP)-Mediated Cytotrophoblast Differentiation

H Shoaito, J Petit, A Chissey, N Auzeil… - Environmental …, 2019 - ehp.niehs.nih.gov
Background: Phthalates are environmental contaminants commonly used as plasticizers in
polyvinyl chloride (PVC) products. Recently, exposure to phthalates has been associated …

Molecular pathways in placental-fetal development and disruption

JJ Adibi, Y Zhao, H Koistinen, RT Mitchell… - Molecular and cellular …, 2024 - Elsevier
The first trimester of pregnancy ranks high in priority when minimizing harmful exposures,
given the wide-ranging types of organogenesis occurring between 4-and 12-weeks' …

Placental outcomes of phthalate exposure

GR Warner, RS Dettogni, IC Bagchi, JA Flaws… - Reproductive …, 2021 - Elsevier
Proper placental development and function relies on hormone receptors and signaling
pathways that make the placenta susceptible to disruption by endocrine disrupting …

A comprehensive assessment of associations between prenatal phthalate exposure and the placental transcriptomic landscape

AG Paquette, J MacDonald, S Lapehn… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: Phthalates are commonly used endocrine-disrupting chemicals that are
ubiquitous in the general population. Prenatal phthalate exposure may alter placental …