The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

Postoperative cognitive dysfunction (POCD) is a severe neurological complication after
anesthesia and surgery. However, there is still a lack of effective clinical pharmacotherapy …

Drug addiction is a chronic and debilitating disease that is considered a global health
problem. Various cell types in the brain are involved in the progression of drug addiction …

Aims Mitochondrial perturbations are the major culprit of the inflammatory response during
the initial phase of cerebral ischemia. The present study explored the neuroprotective effect …

Histone methyltransferases (HMTs) play a critical role in gene post-translational regulation
and diverse physiological processes, and are implicated in a plethora of human diseases …

Sirtuin 6 (SIRT6) is an NAD-dependent deacetylase/deacylase/mono-ADP
ribosyltransferase, a member of the sirtuin protein family. SIRT6 has been implicated in …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, which is
associated with memory deficit and global cognitive decline. Age is the greatest risk factor …

SIRT6 is a member of the Sir2-like family in mammals. Recent structural and biochemical
studies have characterized SIRT6 as having deacetylation, defatty-acylation, and mono-ADP …

Energy restriction (ER) protects against cerebral ischemic injury, but the underlying
mechanism remains largely unclear. Here, rats were fed ad libitum (AL) or on an alternate …