Cyclooxygenases are a group of heme-containing isozymes (namely Cox-1 and Cox-2) that
catalyze the conversion of arachidonic acid to largely bioactive prostaglandins (PGs). Cox-1 …

Neuroinflammation has been implicated in the pathogenesis or the progression of a variety
of acute and chronic neurological and neurodegenerative disorders, including Alzheimer's …

While neuroinflammation is an evolving concept and the cells involved and their functions
are being defined, microglia are understood to be a key cellular mediator of brain injury and …

Neuroinflammation is indicated in the pathogenesis of several acute and chronic
neurological disorders. Acute lesions in the brain parenchyma induce intense and highly …

Abstract Indoleamine 2, 3-dioxygenase (IDO), an enzyme which is activated by pro-
inflammatory cytokines, has been suggested as a potential link between neuroinflammatory …

Objective: The development of sepsis in patients with traumatic brain injury increases
mortality, exacerbates morphological and functional cerebral damage, and causes …

Inflammation is a physiological response to exogenous and endogenous stimuli and,
together with demyelination and immune system activation, is one of the key features of …

Abstract Indoleamine 2, 3-dioxygenase (IDO), an enzyme which is activated by pro-
inflammatory cytokines, has been suggested as a potential link between neuroinflammatory …

The cyclooxygenases COX-1 and COX-2 metabolize arachidonic acid to prostaglandins
(PGs) and thromboxanes and are thought to play a role in neuroinflammation and …

Eicosanoids are signaling molecules generated through enzymic oxidation of arachidonic
acid (ARA, 20: 4n-6) by cyclooxygenases (COX-1 and 2)(O'Banion, 1999; Vane et al., 1998; …