The innate immune system is the first line of host defense against infection and is comprised
of humoral and cellular mechanisms that recognize potential pathogens within minutes or …

Severe malaria remains a major cause of global mortality. The innate immune response to
infection is a key determinant of malaria severity and outcome. The complement system …

Human genome sequencing has resulted in a great body of data, including a stunningly
large number of single nucleotide polymorphisms (SNPs) with unknown phenotypic …

Background. Mannan-binding lectin (MBL), a soluble protein of innate immunity, is known to
play a role in pathogen recognition and clearance. For more than a decade, it has been …

TATA-binding protein (TBP) is the first basal factor that recognizes and binds a TATA box on
TATA-containing gene promoters transcribed by RNA polymerase II. Data available in the …

The use of biomedical SNP markers of diseases can improve effectiveness of treatment.
Genotyping of patients with subsequent searching for SNPs more frequent than in norm is …

ABSTRACT SNP s in ТАТА boxes are the cause of monogenic diseases, contribute to a
large number of complex diseases, and have implications for human sensitivity to external …

Background L-ficolin (encoded by FCN2) binds to acetylated sugar moieties of many
pathogens, including Trypanosoma cruzi, promoting their phagocytosis and lysis by the …

Mannose-binding lectin (MBL) initiates complement on Trypanosoma cruzi through the MBL-
associated serine protease 2 (MASP2). We haplotyped six MASP2 polymorphisms in 208 …

Hepatitis C virus (HCV) is a major cause of hepatic disease and of liver transplantation
worldwide. Mannan-binding lectin (MBL), encoded by the MBL2 gene, can have an …