[HTML][HTML] Bridging bench to body: ex vivo models to understand articular cartilage repair

A Trengove, S Duchi, C Onofrillo… - Current Opinion in …, 2024 - Elsevier
Highlights•Novel articular cartilage tissue engineering therapies have been
developed.•Integration of engineered tissue with native cartilage is an ongoing …

Potential applications of mesenchymal stem cells and their derived exosomes in regenerative medicine

M Adelipour, DM Lubman, J Kim - Expert opinion on biological …, 2023 - Taylor & Francis
Introduction Regenerative medicine involves the replacement of damaged cells, tissues, or
organs to restore normal function. Mesenchymal stem cells (MSCs) and exosomes secreted …

Visualizable and lubricating hydrogel microspheres via NanoPOSS for cartilage regeneration

Y Yao, G Wei, L Deng, W Cui - Advanced Science, 2023 - Wiley Online Library
The monitoring of tissue regeneration is particularly important. However, most materials do
not allow direct observation of the regeneration process in the cartilage layer. Here, using …

Injectable, Self‐Contained, Subaqueously Cross‐Linking Laminous Adhesives for Biophysical‐Chemical Modulation of Osteochondral Microenvironment

T Xu, Y Yang, EHL Yeung, Q Chen… - Advanced Functional …, 2023 - Wiley Online Library
Current osteochondral (OC) defect repair approaches using premade scaffolds face clinical
limitations due to invasiveness, weak integrity, and/or insufficient interfacial bonding. An …

Enhancing stem cell therapy for cartilage repair in osteoarthritis—a hydrogel focused approach

Y Liu, M Wang, Y Luo, Q Liang, Y Yu, F Chen, J Yao - Gels, 2021 - mdpi.com
Stem cells hold tremendous promise for the treatment of cartilage repair in osteoarthritis. In
addition to their multipotency, stem cells possess immunomodulatory effects that can …

Controlled-Release Hydrogel Microspheres to Deliver Multipotent Stem Cells for Treatment of Knee Osteoarthritis

M Hamilton, J Wang, P Dhar, L Stehno-Bittel - Bioengineering, 2023 - mdpi.com
Osteoarthritis (OA) is the most common form of joint disease affecting articular cartilage and
peri-articular tissues. Traditional treatments are insufficient, as they are aimed at mitigating …

[HTML][HTML] Cartilage responses to inflammatory stimuli and adipose stem/stromal cell-derived conditioned medium: Results from an ex vivo model

F Cadelano, E Della Morte, S Niada, F Anzano… - Regenerative …, 2024 - Elsevier
Introduction Osteoarthritis (OA), a chronic inflammatory joint disorder, still lacks effective
therapeutic interventions. Consequently, the development of convenient experimental …

Functionalized hydrogels for cartilage repair: the value of secretome-instructive signaling

MJ Barisón, R Nogoceke, R Josino… - International Journal of …, 2022 - mdpi.com
Cartilage repair has been a challenge in the medical field for many years. Although
treatments that alleviate pain and injury are available, none can effectively regenerate the …

Controlling microenvironments with organs-on-chips for osteoarthritis modelling

LJY Ong, X Fan, A Rujia Sun, L Mei, YC Toh… - Cells, 2023 - mdpi.com
Osteoarthritis (OA) remains a prevalent disease affecting more than 20% of the global
population, resulting in morbidity and lower quality of life for patients. The study of OA …

Droplet Microfluidics Powered Hydrogel Microparticles for Stem Cell‐Mediated Biomedical Applications

F Zheng, R Tian, H Lu, X Liang, M Shafiq, S Uchida… - Small, 2024 - Wiley Online Library
Stem cell‐related therapeutic technologies have garnered significant attention of the
research community for their multi‐faceted applications. To promote the therapeutic effects …