Role of alcohol oxidative metabolism in its cardiovascular and autonomic effects

MM El-Mas, AA Abdel-Rahman - … to Human Health and Precision Medicine, 2019 - Springer
Several review articles have been published on the neurobehavioral actions of
acetaldehyde and other ethanol metabolites as well as in major alcohol-related disorders …

Ethanol‐induced c‐fos expression in catecholamine‐and neuropeptide Y‐producing neurons in rat brainstem

TE Thiele, I Cubero, G Van Dijk… - Alcoholism: Clinical …, 2000 - Wiley Online Library
Background: Previous studies have used c‐Fos‐like immunoreactivity (cFLI) to examine the
neuroanatomical location of cells that are activated in response to ethanol administration …

Facilitation of myocardial PI3K/Akt/nNOS signaling contributes to ethanol‐evoked hypotension in female rats

MM El‐Mas, M Fan… - Alcoholism: Clinical and …, 2009 - Wiley Online Library
Background: The mechanism by which ethanol reduces cardiac output (CO) and blood
pressure (BP) in female rats remains unclear. We tested the hypothesis that enhancement of …

Influence of gender on the association of alcohol drinking with blood pressure

I Wakabayashi - American journal of hypertension, 2008 - academic.oup.com
Background The purpose of this study was to determine whether gender influences the
association of alcohol drinking with blood pressure. Methods The subjects (43,810 healthy …

Upregulation of vascular inducible nitric oxide synthase mediates the hypotensive effect of ethanol in conscious female rats

MM El-Mas, J Zhang… - Journal of Applied …, 2006 - journals.physiology.org
Previous reports from our laboratory have shown that ethanol elicits hypotension in female
but not in male rats and that this effect of ethanol is estrogen dependent (El-Mass MM and …

Ovariectomy exacerbates acute ethanol-induced tachycardia: role of nitric oxide and NMDA receptors in the rostral ventrolateral medulla

JH Situmorang, HH Lin, MS Islam, CC Lai - International Journal of …, 2023 - mdpi.com
Ethanol consumption influences cardiovascular functions. In humans, acute consumption of
ethanol causes dose-dependent tachycardia. Our previous study showed that ethanol …

Oxidative stress and autonomic dysregulation contribute to the acute time‐dependent myocardial depressant effect of ethanol in conscious female rats

BM Ibrahim, M Fan… - Alcoholism: Clinical and …, 2014 - Wiley Online Library
Background The molecular mechanisms of the acute hypotensive and indirectly assessed
cardiac depressant effect of ethanol (E t OH)‐evoked myocardial depression and …

Nongenomic effects of estrogen mediate the dose-related myocardial oxidative stress and dysfunction caused by acute ethanol in female rats

MM El-Mas, AA Abdel-Rahman - American Journal of …, 2014 - journals.physiology.org
Acute ethanol lowers blood pressure (BP) and cardiac output in proestrus and after chronic
estrogen (E2) replacement in ovariectomized (OVX) female rats. However, whether rapid …

Estrogen modulation of the ethanol-evoked myocardial oxidative stress and dysfunction via DAPK3/Akt/ERK activation in male rats

MM El-Mas, AA Abdel-Rahman - Toxicology and applied pharmacology, 2015 - Elsevier
Evidence suggests that male rats are protected against the hypotensive and myocardial
depressant effects of ethanol compared with females. We investigated whether E 2 modifies …

Estrogen receptors α and β play major roles in ethanol‐evoked myocardial oxidative stress and dysfunction in conscious ovariectomized rats

F Yao, AA Abdel‐Rahman - Alcoholism: Clinical and …, 2017 - Wiley Online Library
Background We documented the dependence of ethanol (EtOH)‐evoked myocardial
dysfunction on estrogen (E2), and our recent estrogen receptor (ER) blockade study, in …