Myokines are muscle‐derived cytokines and chemokines that act extensively on organs and
exert beneficial metabolic functions in the whole‐body through specific signal networks …

Background Inflammation, oxidative stress, and apoptosis contribute to the evolution of
doxorubicin (DOX)‐induced cardiotoxicity. Osteocrin (OSTN) is a novel secretory peptide …

Cardiac fibrosis plays a key role in the progression of diabetic cardiomyopathy (DCM).
Previous studies demonstrated the cardioprotective effects of natriuretic peptides. However …

Cachexia is associated with poor prognosis in chronic heart failure patients, but the
underlying mechanisms of cachexia triggered disease progression remain poorly …

Proteasomal activity is compromised in diabetic hearts that contributes to proteotoxic
stresses and cardiac dysfunction. Osteocrin (OSTN) acts as a novel exercise-responsive …

Achondroplasia is the most common form of disproportionate short stature. A dominantly
inherited FGFR3 mutation permanently activates the fibroblast growth factor receptor 3 …

Mechanical stimuli including loading after birth promote bone growth. However, little is
known about how mechanical force triggers biochemical signals to regulate bone growth …

Some osteoblasts embed within bone matrix, change shape, and become dendrite-bearing
osteocytes. The circuitry that drives dendrite formation during “osteocytogenesis” is poorly …

Previous studies suggested a beneficial effect of natriuretic peptides in animal models of
cardiovascular disease, but the role of natriuretic peptide receptor C (NPRC) in the …

Rationale: An increase of severe ischemic heart diseases results in an increase of the
patients with congestive heart failure (CHF). Therefore, new therapies are expected in …