Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
Insulin-degrading enzyme in the fight against Alzheimer's disease
After decades of research and clinical trials there is still no cure for Alzheimer's disease
(AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the …
(AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the …
Insulin‐degrading enzyme: an ally against metabolic and neurodegenerative diseases
L Sousa, M Guarda, MJ Meneses… - The Journal of …, 2021 - Wiley Online Library
Insulin‐degrading enzyme (IDE) function goes far beyond its known proteolytic role as a
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …
Are amyloid‐degrading enzymes viable therapeutic targets in Alzheimer's disease?
NN Nalivaeva, C Beckett, ND Belyaev… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120 (Suppl. 1), 167–185. Abstract The amyloid cascade hypothesis of
Alzheimer's disease envisages that the initial elevation of amyloid β‐peptide (Aβ) levels …
Alzheimer's disease envisages that the initial elevation of amyloid β‐peptide (Aβ) levels …
Modulation of insulin sensitivity by insulin-degrading enzyme
CM González-Casimiro, B Merino… - Biomedicines, 2021 - mdpi.com
Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …
metalloprotease that degrades insulin and several other intermediate-size peptides. For …
Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin
The accumulation of aggregates of amyloidogenic peptides is associated with numerous
human diseases. One well studied example is the association between deposition of …
human diseases. One well studied example is the association between deposition of …
Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner
The insulin-degrading enzyme (IDE) degrades amyloidogenic proteins such as Amyloid β
(Αβ) and Islet Amyloid Polypeptide (IAPP), ie peptides associated with Alzheimer's disease …
(Αβ) and Islet Amyloid Polypeptide (IAPP), ie peptides associated with Alzheimer's disease …
Targeting insulin-degrading enzyme to treat type 2 diabetes mellitus
WJ Tang - Trends in endocrinology & metabolism, 2016 - cell.com
Insulin-degrading enzyme (IDE) selectively degrades peptides, such as insulin, amylin, and
amyloid β (Aβ) that form toxic aggregates, to maintain proteostasis. IDE defects are linked to …
amyloid β (Aβ) that form toxic aggregates, to maintain proteostasis. IDE defects are linked to …
Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
GR Tundo, D Sbardella, C Ciaccio… - Critical reviews in …, 2017 - Taylor & Francis
Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family,
which has been initially discovered as the enzyme responsible for insulin catabolism; …
which has been initially discovered as the enzyme responsible for insulin catabolism; …