The apoptosis paradox in cancer

O Morana, W Wood, CD Gregory - International journal of molecular …, 2022 - mdpi.com
Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions

N Bister, C Pistono, B Huremagic… - Journal of …, 2020 - Wiley Online Library
Hypoxia is an essential hallmark of several serious diseases such as cardiovascular and
metabolic disorders and cancer. A decline in the tissue oxygen level induces hypoxic …

Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes

C Zheng, B Sui, X Zhang, J Hu, J Chen… - Journal of …, 2021 - Wiley Online Library
Apoptosis is a naturally occurring process generating plenty of apoptotic vesicles (apoVs),
but the feature, fate and function of apoVs remain largely unknown. Notably, as an …

Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

Apoptotic bodies for advanced drug delivery and therapy

M Zhou, YJ Li, YC Tang, XY Hao, WJ Xu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …

Extracellular vesicles as signaling mediators and disease biomarkers across biological barriers

P Simeone, G Bologna, P Lanuti… - International journal of …, 2020 - mdpi.com
Extracellular vesicles act as shuttle vectors or signal transducers that can deliver specific
biological information and have progressively emerged as key regulators of organized …

Apoptotic extracellular vesicles ameliorate multiple myeloma by restoring fas-mediated apoptosis

J Wang, Z Cao, P Wang, X Zhang, J Tang, Y He… - ACS …, 2021 - ACS Publications
Apoptosis is critical for maintaining bodily homeostasis and produces a large number of
apoptotic extracellular vesicles (apoEVs). Several types of cancer cells display reduced …

In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo: Part I: Health and Normal Physiology

AG Yates, RC Pink, U Erdbrügger… - Journal of …, 2022 - Wiley Online Library
Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are
now known to mediate physiological and pathological functions throughout the body. We …

Horizontal gene transfer: from evolutionary flexibility to disease progression

M Emamalipour, K Seidi, S Zununi Vahed… - Frontiers in cell and …, 2020 - frontiersin.org
Flexibility in the exchange of genetic material takes place between different organisms of the
same or different species. This phenomenon is known to play a key role in the genetic …

Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials

L Yu, G Zhu, Z Zhang, Y Yu, L Zeng, Z Xu… - Journal of …, 2023 - Springer
Apoptosis, a form of programmed cell death, is essential for growth and tissue homeostasis.
Apoptotic bodies (ApoBDs) are a form of extracellular vesicles (EVs) released by dying cells …