Modern societies are experiencing an increasing trend of reduced sleep duration, with
nocturnal sleeping time below the recommended ranges for health. Epidemiological and …

Sleep-immune interactions are well-known phenomena in everyday life and folk wisdom.
There is no doubt that an infection makes us tired and increases the desire to sleep, and a …

The discovery of reciprocal connections between the central nervous system, sleep and the
immune system has shown that sleep enhances immune defences and that afferent signals …

Sleep disturbances including insomnia independently contribute to risk of inflammatory
disorders and major depressive disorder. This review and overview provides an integrated …

Sleep has a critical role in promoting health. Research over the past decade has
documented that sleep disturbance has a powerful influence on the risk of infectious …

Innate immune responses are regulated by microorganisms and cell death, as well as by a
third class of stress signal from the nervous and endocrine systems. The innate immune …

Background Infectious, autoimmune, and neurodegenerative diseases are associated with
profound psychological disturbances. Studies in animals clearly demonstrate that cytokines …

Controlled, experimental studies on the effects of acute sleep loss in humans have shown
that mediators of inflammation are altered by sleep loss. Elevations in these mediators have …

Good sleep is necessary for physical and mental health. For example, sleep loss impairs
immune function, and sleep is altered during infection. Immune signalling molecules are …

Increasing evidence from animal and human studies suggests that inflammation may be
involved in mood disorders. Sickness behavior and emotional changes induced by …